Effect of scaling and root planing on gingival crevicular fluid levels of adrenomedullin in chronic periodontitis patients with and without diabetes mellitus type 2: A clinico-biochemical study.
Identifieur interne : 000053 ( Main/Exploration ); précédent : 000052; suivant : 000054Effect of scaling and root planing on gingival crevicular fluid levels of adrenomedullin in chronic periodontitis patients with and without diabetes mellitus type 2: A clinico-biochemical study.
Auteurs : Lavanya Pragada [Inde] ; Dhoom Singh Mehta [Inde] ; V. Manasa [Inde] ; Chandrahas Gangaram Bathini [Inde] ; Sneha Kesari [Inde] ; Ritika Bansal [États-Unis]Source :
- Annals of African medicine [ 0975-5764 ]
Descripteurs français
- KwdFr :
- Adrénomédulline (analyse), Adrénomédulline (métabolisme), Adrénomédulline (sang), Adulte (MeSH), Adulte d'âge moyen (MeSH), Diabète de type 2 (complications), Diabète de type 2 (métabolisme), Diabète de type 2 (sang), Détartrage dentaire (MeSH), Exsudat gingival (composition chimique), Femelle (MeSH), Humains (MeSH), Mâle (MeSH), Parodontite chronique (complications), Parodontite chronique (métabolisme), Surfaçage radiculaire (MeSH), Études cas-témoins (MeSH), Études prospectives (MeSH).
- MESH :
- analyse : Adrénomédulline.
- composition chimique : Diabète de type 2, Exsudat gingival, Parodontite chronique.
- métabolisme : Adrénomédulline, Diabète de type 2, Parodontite chronique.
- sang : Adrénomédulline, Diabète de type 2.
- Adulte, Adulte d'âge moyen, Détartrage dentaire, Femelle, Humains, Mâle, Surfaçage radiculaire, Études cas-témoins, Études prospectives.
English descriptors
- KwdEn :
- Adrenomedullin (analysis), Adrenomedullin (blood), Adrenomedullin (metabolism), Adult (MeSH), Case-Control Studies (MeSH), Chronic Periodontitis (complications), Chronic Periodontitis (metabolism), Dental Scaling (MeSH), Diabetes Mellitus, Type 2 (blood), Diabetes Mellitus, Type 2 (complications), Diabetes Mellitus, Type 2 (metabolism), Female (MeSH), Gingival Crevicular Fluid (chemistry), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Prospective Studies (MeSH), Root Planing (MeSH).
- MESH :
- chemical , analysis : Adrenomedullin.
- chemical , blood : Adrenomedullin.
- chemical , metabolism : Adrenomedullin.
- blood : Diabetes Mellitus, Type 2.
- chemistry : Gingival Crevicular Fluid.
- complications : Chronic Periodontitis, Diabetes Mellitus, Type 2.
- metabolism : Chronic Periodontitis, Diabetes Mellitus, Type 2.
- Adult, Case-Control Studies, Dental Scaling, Female, Humans, Male, Middle Aged, Prospective Studies, Root Planing.
Abstract
Background
Increased plasma adrenomedullin levels are usually observed in certain conditions such as diabetes mellitus (DM).
Aims and Objectives
To gauge adrenomedullin values in the gingival crevicular fluid (GCF) of healthy individuals, chronic periodontitis (CP) patients with and without DM, and diabetics without any periodontal involvement, prior and after periodontal therapy.
Materials and Methods
A total of 120 subjects were segregated into four categories of 30 each: Group 1 (healthy subjects), Group 2 (CP without DM), Group 3 (patients with CP and DM), and Group 4 (diabetics without any periodontal involvement). GCF was collected from all the patients. Nonsurgical periodontal therapy was done in Group 2 and Group 3 patients, followed up for 6 weeks, and GCF was obtained again from the same site. Enzyme-linked immunosorbent assay was used to evaluate the samples.
Results
Adrenomedullin level in the GCF was high in diabetics without any periodontal involvement than in healthy individuals and significantly elevated in those with CP and DM. Reduced adrenomedullin was noted 6 weeks postperiodontal therapy.
Conclusion
Adrenomedullin levels being higher in diabetics without any periodontal involvement than healthy controls suggest a link between DM and adrenomedullin. Furthermore, infection plays a noteworthy role in the elevation of adrenomedullin, indicating its role in periodontal disease progression.
Résumé Contexte: Des taux plasmatiques d'adrénomédulline accrus sont généralement observés dans certaines conditions telles que le diabète sucré. Buts et objectifs:Évaluer les valeurs de l'adrénomédulline dans le liquide creviculaire gingival (GCF) des individus sains, chroniques parodontite (PC) patients avec et sans DM, et diabétiques sans atteinte parodontale, avant et après traitement parodontal. Matériels et méthodes: Un total de 120 sujets ont été séparés en quatre catégories de 30 chacun: Groupe 1 (sujets sains), groupe 2 (CP sans DM), groupe 3 (patients avec CP et DM) et groupe 4 (diabétiques sans atteinte parodontale). GCF a été collecté de tous les patients. La thérapie parodontale non chirurgicale a été réalisée chez les patients des groupes 2 et 3, suivie pendant 6 semaines et le GCF obtenu à nouveau du même site. Un dosage immunoenzymatique a été utilisé pour évaluer les échantillons. Résultats: taux d'adrénomédulline dans le GCF était élevé chez les diabétiques sans atteinte parodontale que chez les individus sains et significativement élevés chez ceux avec CP et DM. Une réduction de l'adrénomédulline a été notée 6 semaines après la thérapie post-parodontale. Conclusion: les taux d'adrénomédulline étant plus élevés chez les diabétiques sans atteinte parodontale que les contrôles sains suggèrent un lien entre le diabète et l'adrénomédulline. De plus, l'infection joue un rôle rôle important dans l'élévation de l'adrénomédulline, indiquant son rôle dans la progression de la maladie parodontale.
DOI: 10.4103/aam.aam_40_18
PubMed: 31070151
PubMed Central: PMC6521633
Affiliations:
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Manasa</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oral Pathology, Celebrity Smiles Dental Clinic, Bangalore, Karnataka, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Oral Pathology, Celebrity Smiles Dental Clinic, Bangalore, Karnataka</wicri:regionArea><wicri:noRegion>Karnataka</wicri:noRegion></affiliation></author><author><name sortKey="Bathini, Chandrahas Gangaram" sort="Bathini, Chandrahas Gangaram" uniqKey="Bathini C" first="Chandrahas Gangaram" last="Bathini">Chandrahas Gangaram Bathini</name><affiliation wicri:level="1"><nlm:affiliation>Department of Periodontics, Dr. Hedgewar Smruti Rugna Seva Mandals Dental College and Hospital, Hingoli, Maharastra, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Dr. Hedgewar Smruti Rugna Seva Mandals Dental College and Hospital, Hingoli, Maharastra</wicri:regionArea><wicri:noRegion>Maharastra</wicri:noRegion></affiliation></author><author><name sortKey="Kesari, Sneha" sort="Kesari, Sneha" uniqKey="Kesari S" first="Sneha" last="Kesari">Sneha Kesari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Periodontics, Dhanbad Nursing Home (P) Ltd, Amri Hospital, Kolkata, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Periodontics, Dhanbad Nursing Home (P) Ltd, Amri Hospital, Kolkata</wicri:regionArea><wicri:noRegion>Kolkata</wicri:noRegion></affiliation></author><author><name sortKey="Bansal, Ritika" sort="Bansal, Ritika" uniqKey="Bansal R" first="Ritika" last="Bansal">Ritika Bansal</name><affiliation wicri:level="2"><nlm:affiliation>General Dentist, First Choice Community Health Center, Connecticut, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>General Dentist, First Choice Community Health Center, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author></analytic><series><title level="j">Annals of African medicine</title><idno type="eISSN">0975-5764</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenomedullin (analysis)</term><term>Adrenomedullin (blood)</term><term>Adrenomedullin (metabolism)</term><term>Adult (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Chronic Periodontitis (complications)</term><term>Chronic Periodontitis (metabolism)</term><term>Dental Scaling (MeSH)</term><term>Diabetes Mellitus, Type 2 (blood)</term><term>Diabetes Mellitus, Type 2 (complications)</term><term>Diabetes Mellitus, Type 2 (metabolism)</term><term>Female (MeSH)</term><term>Gingival Crevicular Fluid (chemistry)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Prospective Studies (MeSH)</term><term>Root Planing (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adrénomédulline (analyse)</term><term>Adrénomédulline (métabolisme)</term><term>Adrénomédulline (sang)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Diabète de type 2 (complications)</term><term>Diabète de type 2 (métabolisme)</term><term>Diabète de type 2 (sang)</term><term>Détartrage dentaire (MeSH)</term><term>Exsudat gingival (composition chimique)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Parodontite chronique (complications)</term><term>Parodontite chronique (métabolisme)</term><term>Surfaçage radiculaire (MeSH)</term><term>Études cas-témoins (MeSH)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Adrenomedullin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenomedullin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adrenomedullin</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Adrénomédulline</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Diabetes Mellitus, Type 2</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Gingival Crevicular Fluid</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Chronic Periodontitis</term><term>Diabetes Mellitus, Type 2</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Diabète de type 2</term><term>Exsudat gingival</term><term>Parodontite chronique</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Chronic Periodontitis</term><term>Diabetes Mellitus, Type 2</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adrénomédulline</term><term>Diabète de type 2</term><term>Parodontite chronique</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Adrénomédulline</term><term>Diabète de type 2</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Case-Control Studies</term><term>Dental Scaling</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Root Planing</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Détartrage dentaire</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Surfaçage radiculaire</term><term>Études cas-témoins</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Background</b></p><p>Increased plasma adrenomedullin levels are usually observed in certain conditions such as diabetes mellitus (DM).</p></div><div type="abstract" xml:lang="en"><p><b>Aims and Objectives</b></p><p>To gauge adrenomedullin values in the gingival crevicular fluid (GCF) of healthy individuals, chronic periodontitis (CP) patients with and without DM, and diabetics without any periodontal involvement, prior and after periodontal therapy.</p></div><div type="abstract" xml:lang="en"><p><b>Materials and Methods</b></p><p>A total of 120 subjects were segregated into four categories of 30 each: Group 1 (healthy subjects), Group 2 (CP without DM), Group 3 (patients with CP and DM), and Group 4 (diabetics without any periodontal involvement). GCF was collected from all the patients. Nonsurgical periodontal therapy was done in Group 2 and Group 3 patients, followed up for 6 weeks, and GCF was obtained again from the same site. Enzyme-linked immunosorbent assay was used to evaluate the samples.</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>Adrenomedullin level in the GCF was high in diabetics without any periodontal involvement than in healthy individuals and significantly elevated in those with CP and DM. Reduced adrenomedullin was noted 6 weeks postperiodontal therapy.</p></div><div type="abstract" xml:lang="en"><p><b>Conclusion</b></p><p>Adrenomedullin levels being higher in diabetics without any periodontal involvement than healthy controls suggest a link between DM and adrenomedullin. Furthermore, infection plays a noteworthy role in the elevation of adrenomedullin, indicating its role in periodontal disease progression.</p></div><div type="abstract" xml:lang="fr"><b>Résumé</b> <b>Contexte:</b> Des taux plasmatiques d'adrénomédulline accrus sont généralement observés dans certaines conditions telles que le diabète sucré. <b>Buts et objectifs:</b>Évaluer les valeurs de l'adrénomédulline dans le liquide creviculaire gingival (GCF) des individus sains, chroniques parodontite (PC) patients avec et sans DM, et diabétiques sans atteinte parodontale, avant et après traitement parodontal. <b>Matériels et méthodes:</b> Un total de 120 sujets ont été séparés en quatre catégories de 30 chacun: Groupe 1 (sujets sains), groupe 2 (CP sans DM), groupe 3 (patients avec CP et DM) et groupe 4 (diabétiques sans atteinte parodontale). GCF a été collecté de tous les patients. La thérapie parodontale non chirurgicale a été réalisée chez les patients des groupes 2 et 3, suivie pendant 6 semaines et le GCF obtenu à nouveau du même site. Un dosage immunoenzymatique a été utilisé pour évaluer les échantillons. <b>Résultats:</b> taux d'adrénomédulline dans le GCF était élevé chez les diabétiques sans atteinte parodontale que chez les individus sains et significativement élevés chez ceux avec CP et DM. Une réduction de l'adrénomédulline a été notée 6 semaines après la thérapie post-parodontale. <b>Conclusion:</b> les taux d'adrénomédulline étant plus élevés chez les diabétiques sans atteinte parodontale que les contrôles sains suggèrent un lien entre le diabète et l'adrénomédulline. De plus, l'infection joue un rôle rôle important dans l'élévation de l'adrénomédulline, indiquant son rôle dans la progression de la maladie parodontale.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31070151</PMID><DateCompleted><Year>2019</Year><Month>12</Month><Day>31</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">0975-5764</ISSN><JournalIssue CitedMedium="Internet"><Volume>18</Volume><Issue>2</Issue><PubDate><MedlineDate>2019 Apr-Jun</MedlineDate></PubDate></JournalIssue><Title>Annals of African medicine</Title><ISOAbbreviation>Ann Afr Med</ISOAbbreviation></Journal><ArticleTitle>Effect of scaling and root planing on gingival crevicular fluid levels of adrenomedullin in chronic periodontitis patients with and without diabetes mellitus type 2: A clinico-biochemical study.</ArticleTitle><Pagination><MedlinePgn>92-96</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4103/aam.aam_40_18</ELocationID><Abstract><AbstractText Label="Background">Increased plasma adrenomedullin levels are usually observed in certain conditions such as diabetes mellitus (DM).</AbstractText><AbstractText Label="Aims and Objectives">To gauge adrenomedullin values in the gingival crevicular fluid (GCF) of healthy individuals, chronic periodontitis (CP) patients with and without DM, and diabetics without any periodontal involvement, prior and after periodontal therapy.</AbstractText><AbstractText Label="Materials and Methods">A total of 120 subjects were segregated into four categories of 30 each: Group 1 (healthy subjects), Group 2 (CP without DM), Group 3 (patients with CP and DM), and Group 4 (diabetics without any periodontal involvement). GCF was collected from all the patients. Nonsurgical periodontal therapy was done in Group 2 and Group 3 patients, followed up for 6 weeks, and GCF was obtained again from the same site. Enzyme-linked immunosorbent assay was used to evaluate the samples.</AbstractText><AbstractText Label="Results">Adrenomedullin level in the GCF was high in diabetics without any periodontal involvement than in healthy individuals and significantly elevated in those with CP and DM. Reduced adrenomedullin was noted 6 weeks postperiodontal therapy.</AbstractText><AbstractText Label="Conclusion">Adrenomedullin levels being higher in diabetics without any periodontal involvement than healthy controls suggest a link between DM and adrenomedullin. Furthermore, infection plays a noteworthy role in the elevation of adrenomedullin, indicating its role in periodontal disease progression.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pragada</LastName><ForeName>Lavanya</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Periodontics, Clove Dental Hospital, Hyderabad, Telangana, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mehta</LastName><ForeName>Dhoom Singh</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Department of Periodontics, Bapuji Dental College and Hospital, Davangere, Karnataka, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manasa</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Oral Pathology, Celebrity Smiles Dental Clinic, Bangalore, Karnataka, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bathini</LastName><ForeName>Chandrahas Gangaram</ForeName><Initials>CG</Initials><AffiliationInfo><Affiliation>Department of Periodontics, Dr. Hedgewar Smruti Rugna Seva Mandals Dental College and Hospital, Hingoli, Maharastra, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kesari</LastName><ForeName>Sneha</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Periodontics, Dhanbad Nursing Home (P) Ltd, Amri Hospital, Kolkata, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bansal</LastName><ForeName>Ritika</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>General Dentist, First Choice Community Health Center, Connecticut, United States of America.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>India</Country><MedlineTA>Ann Afr Med</MedlineTA><NlmUniqueID>101231417</NlmUniqueID><ISSNLinking>0975-5764</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>148498-78-6</RegistryNumber><NameOfSubstance UI="D053607">Adrenomedullin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D053607" MajorTopicYN="N">Adrenomedullin</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055113" MajorTopicYN="N">Chronic Periodontitis</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012534" MajorTopicYN="Y">Dental Scaling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003924" MajorTopicYN="N">Diabetes Mellitus, Type 2</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005883" MajorTopicYN="N">Gingival Crevicular Fluid</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016745" MajorTopicYN="Y">Root Planing</DescriptorName></MeshHeading></MeshHeadingList><OtherAbstract Type="Publisher" Language="fre"><AbstractText><b>Résumé</b> <b>Contexte:</b> Des taux plasmatiques d'adrénomédulline accrus sont généralement observés dans certaines conditions telles que le diabète sucré. <b>Buts et objectifs:</b>Évaluer les valeurs de l'adrénomédulline dans le liquide creviculaire gingival (GCF) des individus sains, chroniques parodontite (PC) patients avec et sans DM, et diabétiques sans atteinte parodontale, avant et après traitement parodontal. <b>Matériels et méthodes:</b> Un total de 120 sujets ont été séparés en quatre catégories de 30 chacun: Groupe 1 (sujets sains), groupe 2 (CP sans DM), groupe 3 (patients avec CP et DM) et groupe 4 (diabétiques sans atteinte parodontale). GCF a été collecté de tous les patients. La thérapie parodontale non chirurgicale a été réalisée chez les patients des groupes 2 et 3, suivie pendant 6 semaines et le GCF obtenu à nouveau du même site. Un dosage immunoenzymatique a été utilisé pour évaluer les échantillons. <b>Résultats:</b> taux d'adrénomédulline dans le GCF était élevé chez les diabétiques sans atteinte parodontale que chez les individus sains et significativement élevés chez ceux avec CP et DM. Une réduction de l'adrénomédulline a été notée 6 semaines après la thérapie post-parodontale. <b>Conclusion:</b> les taux d'adrénomédulline étant plus élevés chez les diabétiques sans atteinte parodontale que les contrôles sains suggèrent un lien entre le diabète et l'adrénomédulline. De plus, l'infection joue un rôle rôle important dans l'élévation de l'adrénomédulline, indiquant son rôle dans la progression de la maladie parodontale.</AbstractText></OtherAbstract><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Adrenomedullin</Keyword><Keyword MajorTopicYN="Y">chronic periodontitis</Keyword><Keyword MajorTopicYN="Y">diabetes mellitus</Keyword><Keyword MajorTopicYN="Y">gingival crevicular fluid</Keyword></KeywordList><CoiStatement>None</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>5</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>5</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>1</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId 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IdType="pubmed">15330946</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Inde</li><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><country name="Inde"><noRegion><name sortKey="Pragada, Lavanya" sort="Pragada, Lavanya" uniqKey="Pragada L" first="Lavanya" last="Pragada">Lavanya Pragada</name></noRegion><name sortKey="Bathini, Chandrahas Gangaram" sort="Bathini, Chandrahas Gangaram" uniqKey="Bathini C" first="Chandrahas Gangaram" last="Bathini">Chandrahas Gangaram Bathini</name><name sortKey="Kesari, Sneha" sort="Kesari, Sneha" uniqKey="Kesari S" first="Sneha" last="Kesari">Sneha Kesari</name><name sortKey="Manasa, V" sort="Manasa, V" uniqKey="Manasa V" first="V" last="Manasa">V. Manasa</name><name sortKey="Mehta, Dhoom Singh" sort="Mehta, Dhoom Singh" uniqKey="Mehta D" first="Dhoom Singh" last="Mehta">Dhoom Singh Mehta</name></country><country name="États-Unis"><region name="Connecticut"><name sortKey="Bansal, Ritika" sort="Bansal, Ritika" uniqKey="Bansal R" first="Ritika" last="Bansal">Ritika Bansal</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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